|Calculated MW||350687 Da|
|Purification||Antisera to ATM were raised by repeated immunisation of rabbits with highly purified antigen.|
|Immunogen||Recombinant human ATM fragment (amino acids 1-308).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Serine-protein kinase ATM, 22.214.171.124, Ataxia telangiectasia mutated, A-T mutated, ATM|
|Target/Specificity||ABD11297 recognises the human ATM protein, a 350kD polypeptide that is the product of the ATM gene. The ATM gene is defective in Ataxia telangiectasia. ATM protein is expressed within the nucleus of all normal cells, and is thought to be important in detection of DNA damage.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-ATM (aa1-308) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Lakin, N.D. et al. (1996) Analysis of the ATM protein in wild-type and ataxia telangiectasia cells.Oncogene. 13 (12): 2707-16. 2. Jones, G.G. et al. (2004) The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes.Oncogene. 23 (10): 1911-21. 3. Neal, J.A. et al. (2011) Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.Mol Cell Biol. 31 (8): 1719-33. 4. Shrivastav, M. et al. (2009) DNA-PKcs and ATM co-regulate DNA double-strand break repair.DNA Repair (Amst). 8: 920-9. 5. Pettitt, A.R. et al. (2001) p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation.Blood. 98 (3): 814-22. 6. Henriksson, G. et al. (2004) Enhanced DNA-dependent protein kinase activity in Sjögren's syndrome B cells.Rheumatology (Oxford). 43: 1109-15.
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