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Anti-ATM (aa1-308) Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13315
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 350687 Da
Additional Information
Other Species M,Ha,Pr
Purification Antisera to ATM were raised by repeated immunisation of rabbits with highly purified antigen.
Immunogen Recombinant human ATM fragment (amino acids 1-308).
Shelf Life 18 months from date of despatch.
Gene ID 472
Other Names Serine-protein kinase ATM,, Ataxia telangiectasia mutated, A-T mutated, ATM
Target/Specificity ABD11297 recognises the human ATM protein, a 350kD polypeptide that is the product of the ATM gene. The ATM gene is defective in Ataxia telangiectasia. ATM protein is expressed within the nucleus of all normal cells, and is thought to be important in detection of DNA damage.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-ATM (aa1-308) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Lakin, N.D. et al. (1996) Analysis of the ATM protein in wild-type and ataxia telangiectasia cells.
Oncogene. 13 (12): 2707-16. 2. Jones, G.G. et al. (2004) The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes.
Oncogene. 23 (10): 1911-21. 3. Neal, J.A. et al. (2011) Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.
Mol Cell Biol. 31 (8): 1719-33. 4. Shrivastav, M. et al. (2009) DNA-PKcs and ATM co-regulate DNA double-strand break repair.
DNA Repair (Amst). 8: 920-9. 5. Pettitt, A.R. et al. (2001) p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation.
Blood. 98 (3): 814-22. 6. Henriksson, G. et al. (2004) Enhanced DNA-dependent protein kinase activity in Sjögren's syndrome B cells.
Rheumatology (Oxford). 43: 1109-15.

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Cat# ABD11297
(40 western blots)
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