|Application ||WB, IHC-F, FC, IP|
|Calculated MW||39746 Da|
|Purification||Purified IgG prepared by ion exchange chromatography|
|Immunogen||Peptide sequence corresponding to amino acids 1-14 of human CD184 / CXCR4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184, CXCR4|
|Target/Specificity||Rabbit anti-Human CD184 / CXCR4 antibody recognizes the human G-protein-coupled chemokine receptor CD184, also known as CXCR4. CD184 is a 352 amino acid ~40 kDa cell surface protein known to act as a co-factor in HIV infection of CD4+ T cells (Bleulet al.1997). Mutations in the CD184 gene are associated with WHIM syndrome (WHIMS), an inherited combined immunodeficiency disease (Taniuchiet al..).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD184 / CXCR4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Nguyen, D.H. and Taub, D. (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection.J Immunol. 168: 4121-6. 2. Zaitseva, M. et al. (2005) Increased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association.J Leukoc Biol. 78: 1306-17. 3. Taniuchi, S. et al. (2005) The role of a mutation of the CXCR4 gene in WHIM syndrome.Haematologica. 90:1271-1272. 4. Rubie, C. et al. (2008) Differential CXC receptor expression in colorectal carcinomas.Scand J Immunol. 68: 635-44. 5. Rubie, C. et al. (2006) Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases.World J Gastroenterol. 12: 6627-33. 6. Oliveira Frick, V. et al. (2011) Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies.Tumour Biol. 32: 189-96. 7. Moll, N.M. et al. (2009) Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis.Arch Neurol. 66: 44-53.
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