|Application ||WB, IHC-F, IP|
|Calculated MW||76537 Da|
|Purification||Antisera to human IRAK were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.|
|Immunogen||Peptide from C terminus of human IRAK|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-1 receptor-associated kinase 1, IRAK-1, 22.214.171.124, IRAK1, IRAK|
|Target/Specificity||Rabbit anti-Human IRAK1 antibody recognizes human Interleukin-1 receptor-associated kinase 1 (IRAK1) an 80kD serine/threonine protein kinase designated IRAK containing a single protein kinase domain and a single death domain. IRAK is associated with IL-1 receptor subunits, and mediates a signalling cascade leading to NF-kB activation after IL-1 binding (Burnset al.2000).Multiple isoforms of IRAK1 generated by alternative splicing have been described. Isoforms 1 and 2 are ubiquitously expressed (Jensenet al.2001). Rabbit anti-Human IRAK1 antibody recognizes isoform 1 but reactivity with other isoforms having partial deletions of the carboxy-terminal region has not been assessed.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human IRAK1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Cao, Z. et al. (1996) IRAK: a kinase associated with the interleukin-1 receptor.Science 271: 1128-1131.
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