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Anti-GDNFR alpha Antibody

  • WB - Anti-GDNFR alpha Antibody  ABD11315
    Western blot analysis of crude membrane fraction lysates from human brain (B), liver (L), kidney (K) and spleen(S) probed with Rabbit anti Human GDNFR alpha
  • IHC - Anti-GDNFR alpha Antibody  ABD11315
    Immunohistochemical staining of of human brain with Rabbit anti Human GDNFR alpha
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P56159
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 51456 Da
Additional Information
Other Species Rat,M,H
Purification Antisera to human GDNFR alpha were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Immunogen Peptide from C terminus of human GDNFR alpha.
Shelf Life 18 months from date of despatch.
Gene ID 2674
Other Names GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1, GFRA1, GDNFRA, RETL1, TRNR1
Target/Specificity Rabbit anti-GDNFα antibody recognizes GDNFR alpha, also known as GFR&alpha-1 (GFRa Nomenclature Committee 1997), GDNF receptor alpha-1, RET ligand 1 or TGF-beta-related neurotrophic factor receptor 1. GFR&alpha-1 is a 465 amino acid ~52 kDa GPI anchored cell surface receptor for glial cell derived neutrophic factor (GDNF).GFR&alpha-1 is highly expressed in human gliomas (Wiesenhoferet al.2000).
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-GDNFR alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Wiesenhofer, B. et al. (2000) Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GFR-alpha 1) are strongly expressed in human gliomas.
Acta Neuropathol. 99: 131-7. 2. Weis, C. et al. (2001) Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.
Neuroscience. 102: 129-38.1. Jing, S. et al. (1996) GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.
Cell 85: 1113-1124.2. Treanor, J.J.S. et al. (1996) Characterization of a multicomponent receptor for GDNF.
Nature 382: 80-83.3. (1997) Nomenclature of GPI-linked receptors for the GDNF ligand family. GFR(alpha) Nomenclature Committee.
Neuron 19: 485.

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Cat# ABD11315
(40 western blots)
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