|Application ||WB, IHC-P|
|Calculated MW||51456 Da|
|Purification||Antisera to human GDNFR alpha were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.|
|Immunogen||Peptide from C terminus of human GDNFR alpha.|
|Shelf Life||18 months from date of despatch.|
|Other Names||GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1, GFRA1, GDNFRA, RETL1, TRNR1|
|Target/Specificity||Rabbit anti-GDNFα antibody recognizes GDNFR alpha, also known as GFR&alpha-1 (GFRa Nomenclature Committee 1997), GDNF receptor alpha-1, RET ligand 1 or TGF-beta-related neurotrophic factor receptor 1. GFR&alpha-1 is a 465 amino acid ~52 kDa GPI anchored cell surface receptor for glial cell derived neutrophic factor (GDNF).GFR&alpha-1 is highly expressed in human gliomas (Wiesenhoferet al.2000).|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-GDNFR alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Wiesenhofer, B. et al. (2000) Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GFR-alpha 1) are strongly expressed in human gliomas.Acta Neuropathol. 99: 131-7. 2. Weis, C. et al. (2001) Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.Neuroscience. 102: 129-38.1. Jing, S. et al. (1996) GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.Cell 85: 1113-1124.2. Treanor, J.J.S. et al. (1996) Characterization of a multicomponent receptor for GDNF.Nature 382: 80-83.3. (1997) Nomenclature of GPI-linked receptors for the GDNF ligand family. GFR(alpha) Nomenclature Committee.Neuron 19: 485.
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