|Application ||WB, E|
|Calculated MW||42203 Da|
|Purification||Antisera to human fractalkine were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human fractalkine|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1, Processed fractalkine, CX3CL1, FKN, NTT, SCYD1|
|Target/Specificity||Rabbit anti-Human Fractalkine antibody recognizes human fractalkine, otherwise known as CX3CL1, a 397 amino acid CX3C chemokine which signals through the CX3CR1 receptor and is expressed by various tissues including the brain, testis, lung, heart, kidney, colon and skeletal muscle.Adhesion of fractalkine to the CX3CR1 receptor triggers the chemotaxis and adhesion of leucocytes, including T cells, monocytes and NK cells and studies have suggested that fractalkine is involved in the regulation of brain microglia during neuroinflammatory processes (Sunnemarket al.2005). CX3CL1 may also play a role in dendritic cellmediated host defense against invading pathogens such as Legionella pneumophila(Kikuchiet al.2005).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Fractalkine Antibody (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Sunnemark, D. et al. (2005) CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental immune encephalomyelitis: kinetics and cellular origin. J. Neuroinflamm. 2: 17.2. Kikuchi, T. et al. (2005) Involvement of Fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila.Infect. Immun. 73: 5350-5357.
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