|Calculated MW||36572 Da|
|Purification||Antisera to murine ICAD were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 312-331 of mouse ICAD|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit, DFF-45, Inhibitor of CAD, ICAD, Dffa, Icad|
|Target/Specificity||ICAD (Inhibitor of Caspase-Activated DNase) is the murine homologue of human DFF-45.ICAD is cleaved by Caspase-3, releasing CAD which eventually causes degradation of DNA in the nucleus.AHP484 recognises a 45kD band in Western blots.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse ICAD (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Enari, M. et al. (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD.Nature 391: 43-50.2. Sakahira, H. et al. (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.Nature 391: 96-99.3. Wyllie, A. (1998) Apoptosis: An endonuclease at last.Nature 391: 20-21.
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