|Application ||WB, IHC-P|
|Calculated MW||39449 Da|
|Purification||Antisera to murine CAD were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 205-222 of mouse CAD|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA fragmentation factor subunit beta, 3.-.-.-, Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, DNA fragmentation factor 40 kDa subunit, DFF-40, Dffb, Cad|
|Target/Specificity||CAD (Caspase Activated Deoxyribonuclease) is the murine homologue of human DFF-40.CAD is released and activated by caspase cleavage of ICAD, and eventually causes degradation of nuclear DNA.ABD11329 recognises the 40kD CAD in Western blots.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CAD (aa205-222) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Enari, M. et al. (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD.Nature 391: 43-50.2. Sakahira, H. et al. (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.Nature 391: 96-99.3. Liu, X. et al. (1997) DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosisCell 89: 175-184.
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