|Application ||WB, IHC-F|
|Calculated MW||47878 Da|
|Purification||Antisera to human CD262 (DR5) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 388-407 of human CD262 (DR5)|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9|
|Target/Specificity||Rabbit anti-Human CD262 antibody recognizes human Tumor necrosis factor receptor superfamily member 10B, also known as CD262, Death receptor 5 or TNF-related apoptosis-inducing ligand receptor 2. CD262 is a 385 amino acid ~60 kDa single pass type ! transmembrane protein acting as a Receptor for the cytotoxic ligand TNFSF10/TRAIL.Mutations in the TNFRSF10B gene has been implicated in the development of Squamous cell carcinoma of the head and neck (HNSCC) a non melanoma cancer affecting the head and neck.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD262 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Chaudhary, P.M. et al. (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.Immunity. 7 (6): 821-30.
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