|Application ||IHC-P, IHC-F, E|
|Calculated MW||50140 Da|
|Purification||Antisera to Presenilin-2 were raised by repeated immunisation of goats with highly purified antigen.|
|Immunogen||Synthetic peptide corresponding to amino acids 31-47 of Presenilin-2|
|Shelf Life||18 months from date of despatch.|
|Other Names||Presenilin-2, PS-2, 3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2|
|Target/Specificity||Goat anti-Human presenilin-2 antibody recognizes human presenilin-2 (PSEN2), binding to neurons in both normal and Alzheimer's disease brain. Mutation of PSEN2 is associated with the early onset form of autosomal dominant Alzheimer's disease. PSEN2 is an essential component of the gamma-secretase complex along with APH-1 (APH-1A or APH-1B), PSEN1, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.|
|Preservative & Stabilisers||0.1% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Presenilin-2 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Levy-Lahad, E. et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus.Science 269: 973-977.
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