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Anti-Human Presenilin-2 Antibody (Serum)

Goat Anti-Human Polyclonal Antibody

  • IHC - Anti-Human Presenilin-2 Antibody (Serum) ABD11334
    Paraffin embedded mouse kidney stained with Goat anti Human Presenilin-2 followed by rabbit anti goat IgG:HRP
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49810
Other Accession Q61144
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 50140 Da
Additional Information
Other Species M
Purification Antisera to Presenilin-2 were raised by repeated immunisation of goats with highly purified antigen.
Immunogen Synthetic peptide corresponding to amino acids 31-47 of Presenilin-2
Shelf Life 18 months from date of despatch.
Gene ID 5664
Other Names Presenilin-2, PS-2, 3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2
Target/Specificity Goat anti-Human presenilin-2 antibody recognizes human presenilin-2 (PSEN2), binding to neurons in both normal and Alzheimer's disease brain. Mutation of PSEN2 is associated with the early onset form of autosomal dominant Alzheimer's disease. PSEN2 is an essential component of the gamma-secretase complex along with APH-1 (APH-1A or APH-1B), PSEN1, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.
Preservative & Stabilisers 0.1% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Presenilin-2 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Levy-Lahad, E. et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus.
Science 269: 973-977.

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Cat# ABD11334
(40 western blots)
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