|Application ||WB, IHC-P|
|Calculated MW||86943 Da|
|Purification||Antisera to APP were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 672-681 of human APP or 1-10 of the Beta-amyloid peptide 40, Beta-amyloid peptide 42 and C99 peptide.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1|
|Target/Specificity||Rabbit anti-amyloid precursor protein antibody recognises both intact APP and the 4kD Beta-amyloid peptides generated by the action of Beta and Gamma secretases.Deposition of Beta-amyloid peptide in the brain is characteristic of Alzheimer's disease. APP also inhibits Notch signaling through it’s interaction with NUMB (Roncaratiet al.2002).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Amyloid Precursor Protein (aa672-681) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
3. Venezia, V. et al. (2004) Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells.J Neurochem. 90: 1359-70.1. Ponte, P. et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.Nature 331: 525-527.2. Selkoe, D.J. (1994) Cell biology of the amyloid beta protein precursor and the mechanism of Alzheimer's disease.Ann. Rev. Cell. Biol. 10: 373-403.
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