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Anti-Amyloid Precursor Protein (aa672-681) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Amyloid Precursor Protein (aa672-681) Antibody  ABD11340
    Immunohistochemical staining of human brain with Rabbit anti amyloid precursor protein
  • WB - Anti-Amyloid Precursor Protein (aa672-681) Antibody  ABD11340
    Western blot analysis of APP in human (A), mouse (B), and rat (C) brain tissue lysates with Rabbit anti amyloid precursor protein polyclonal antibody
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05067
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 86943 Da
Additional Information
Other Species Rat,M
Purification Antisera to APP were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to amino acids 672-681 of human APP or 1-10 of the Beta-amyloid peptide 40, Beta-amyloid peptide 42 and C99 peptide.
Shelf Life 18 months from date of despatch.
Gene ID 351
Other Names Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1
Target/Specificity Rabbit anti-amyloid precursor protein antibody recognises both intact APP and the 4kD Beta-amyloid peptides generated by the action of Beta and Gamma secretases.Deposition of Beta-amyloid peptide in the brain is characteristic of Alzheimer's disease. APP also inhibits Notch signaling through it’s interaction with NUMB (Roncaratiet al.2002).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Amyloid Precursor Protein (aa672-681) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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3. Venezia, V. et al. (2004) Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells.
J Neurochem. 90: 1359-70.1. Ponte, P. et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
Nature 331: 525-527.2. Selkoe, D.J. (1994) Cell biology of the amyloid beta protein precursor and the mechanism of Alzheimer's disease.
Ann. Rev. Cell. Biol. 10: 373-403.

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Cat# ABD11340
(40 western blots)
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