|Application ||WB, IHC-P|
|Calculated MW||86943 Da|
|Purification||Antisera to APP were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 672-681 of human APP or 1-10 of the Beta-amyloid peptide 40, Beta-amyloid peptide 42 and C99 peptide.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1|
|Target/Specificity||Rabbit anti-amyloid precursor protein antibody recognises both intact APP and the 4kD Beta-amyloid peptides generated by the action of Beta and Gamma secretases.Deposition of Beta-amyloid peptide in the brain is characteristic of Alzheimer's disease. APP also inhibits Notch signaling through it’s interaction with NUMB (Roncaratiet al.2002).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Amyloid Precursor Protein (aa672-681) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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3. Venezia, V. et al. (2004) Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells.J Neurochem. 90: 1359-70.1. Ponte, P. et al. (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.Nature 331: 525-527.2. Selkoe, D.J. (1994) Cell biology of the amyloid beta protein precursor and the mechanism of Alzheimer's disease.Ann. Rev. Cell. Biol. 10: 373-403.
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