|Calculated MW||71845 Da|
|Purification||Antisera to DR6 (NT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide corresponding to amino acids 42-56 of human DR6 precursor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 21, Death receptor 6, CD358, TNFRSF21, DR6|
|Target/Specificity||Rabbit anti-Human DR6 antibody recognizes human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK (Panet al.1998).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human DR6 (aa42-56) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Achiron, A. et al. (2009) Molecular profiling of glatiramer acetate early treatment effects in multiple sclerosis.Dis Markers. 27: 63-73.
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