|Application ||IHC-P, E|
|Purification||Antisera to 8-Hydroxyguanosine were raised by repeated immunisation of goat with highly purified antigen.|
|Immunogen||8-Hydroxyguanosine - conjugate|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||ABD11367 recognises 8-hydroxyguanosine (8-OG), a modified base which occurs in DNA as a result of oxidative stress. 8-hydroxy-2'-deoxyguanosine (8-OHdG) has become a sensitive marker of oxidative damage in cellular DNA and has been reported to be excreted in the urine. Levels of 8-OHdG have been shown to increase on exposure to ionizing radiation and tobacco smoke. ABD11367 cross reacts completely with 8-OHdG.ABD11367 does not cross react with other naturally occurring nucleotides.|
|Preservative & Stabilisers||0.1% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-8-Hydroxyguanosine Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Dwivedi, S. et al. (2012) Butachlor induced dissipation of mitochondrial membrane potential, oxidative DNA damage and necrosis in human peripheral blood mononuclear cellsToxicology. 302: 77-87. 2. Dwivedi, S. et al. (2012) Characterization of coal fly ash nanoparticles and induced oxidative DNA damage in human peripheral blood mononuclear cells.Sci Total Environ. 437: 331-8.
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