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Anti-Human Synphilin 1 Antibody (Serum)

Goat Anti-Human Polyclonal Antibody

  • IF - Anti-Human Synphilin 1 Antibody (Serum) ABD11368
    Published customer image:Goat anti Human synphilin 1 antibody used for immunofluorescenceImage caption:Synphilin-1 interaction with lipid rafts in membranes of mouse primary neurons. A: Pictures obtained by confocal microscopy to determine co-localization of inclusions formed by mouse synphilin-1 with lipid rafts in membranes of mouse primary neuronal cultures. Shown are representative pictures taken at the plane of the neurites (left panels) or of the neuronal cell body (right panels). Synphilin-1 was detected using a goat anti-synphilin 1 as primary antibody and donkey anti-goat IgG (H+L) coupled to Alexa Fluor 568 as secondary antibody. The cholera toxin subunit B served as a marker for lipid rafts. DAPI was used to stain nuclei. The white bar in the upper panel corresponds to a size of 10 µm. B: Interaction with lipid rafts of endogenous SYWT and a-Syn in membranes of mouse primary neuronal cultures. Lipid raft fractions (boxed areas) were identified using the mammalian lipid raft marker flotillin-1. The open arrowhead indicates the position of the 100 kDa molecular weight marker.From: :Büttner S, Delay C, Franssens V, Bammens T, Ruli D, et al. Synphilin-1 Enhances a-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner. PLoS ONE 5: e13700.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6H5
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 100409 Da
Additional Information
Purification Antisera to Synphilin-1 were raised by repeated immunisation of goat with highly purified antigen.
Immunogen Peptide 829SLELNGEKDKDKGRTLQRT847
Shelf Life 18 months from date of despatch.
Gene ID 9627
Other Names Synphilin-1, Sph1, Alpha-synuclein-interacting protein, SNCAIP
Target/Specificity ABD11368 recognises synphilin-1, a cytoplasmic protein which associates with alpha-synuclein in vivo. Alpha-Synuclein is a major component of lewy bodies in patients with sporadic Parkinson's disease (PD) and mutations of alpha-synuclein are involved in familial forms of PD. Reports suggest that synphilin-1 may play a role in lewy body formation in association with alpha synuclein.
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Synphilin 1 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Buttner, S. et al. (2010) Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.
PloS ONE 5: e13700.

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Cat# ABD11368
(40 western blots)
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