|Application ||WB, IHC-P, E, Func|
|Calculated MW||42803 Da|
|Purification||Antisera to Human RAGE were raised by repeated immunisation of goats with highly purified antigen.|
|Immunogen||Synthetic peptide, PKKPPQRLEWKLNTGRTE, corresponding to amino acids 42-59 of human RAGE.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER, RAGE|
|Target/Specificity||Goat anti-Human RAGE antibody recognises the human Advanced glycosylation end product-specific receptor, also known as Receptor for Advanced Glycation End products (RAGE). RAGE is a 404 amino acid ~45 kDa single pass type 1 transmembrane glycoprotein bearing two Ig-like C2-type and a single Ig-like V-type domain. RAGE is a member of the Immunoglobulin superfamily which binds a variety of ligands including advanced glycation end products (AGEs) and amyloid fibrils. RAGE is expressed by endothelium, mononuclear phagocytes, smooth muscle and neurons. RAGE may be involved in a range of pathological conditions including diabetes (Ndipet al.2014) and Alzheimer's disease (Matroneet al.2014).|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human RAGE Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Schmidt, A.M. et al. (1996) RAGE: a novel cellular receptor for advanced glycation end products. Diabetes. 45: S77 - 80. 2. Sugars, R. et al. (2007) Expression of HMGB1 during tooth development.Cell Tissue Res 327: 511–9. 3. Rodríguez-Ayala, E. et al. (2005) Enhanced RAGE-mediated NFkappaB stimulation in inflamed hemodialysis patients.Atherosclerosis. 180: 333-40. 4. Gomez, A. & Ferrer, I. (2010) Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment. Acta Neuropathol. 120: 155-67. 5. Aris, J.P. et al. (2010) Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats.J Periodontol. 81: 1481-7. 6. Sugars, R. et al. (2007) Expression of HMGB1 during tooth development.Cell Tissue Res. 327: 511-9. 7. Slowik, A. et al. (2012) Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells.Mol Neurodegener. 7: 55. 8. Abdulahad, D. et al. (2013) High mobility group box1 (HMGB1) in relation to cutaneous inflammation in systemic lupus erythematosus (SLE).Lupus. 22: 597-606. 9. Heilmann, .M. et al. (2014) Systemic levels of the anti-inflammatory decoy receptor soluble RAGE (receptor for advanced glycation end products) are decreased in dogs with inflammatory bowel disease.Vet Immunol Immunopathol. 161: 184-92. 10. Khanna, S. et al. (2014) Excessive α-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke.FASEB J. pii: fj.14-263723. 11. González-López, A. et al. (2012) MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.PLoS One. 7(6):e39940. 12. Regan JK et al. (2015) Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep.Reprod Sci. pii: 1933719115594014. 13. Ko, Y.H. et al. (2015) Methylprednisolone Protects Cardiac Pumping Mechanics from Deteriorating in Lipopolysaccharide-Treated Rats.Front Physiol. 6: 348.
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