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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Anti-Human RAGE Antibody (Serum)   

Anti-Human RAGE Antibody (Serum)

Goat Anti-Human Polyclonal Antibody

     
  • WB - Anti-Human RAGE Antibody (Serum) ABD11369
    Published customer image:Chemokine levels in lung tissue. N = 7/group. LPS injection increased levels of MIP-1a (A, p
  • ICC - Anti-Human RAGE Antibody (Serum) ABD11369
    Published customer image:FPR1 and FPRL1 are co-localised with RAGE in transfected HEK293 cells. FPR1 (A) or FPRL1 (B) and RAGE or ?RAGE transfected HEK293 cells were fixed and labelled with anti-FPR1 (A) or anti-FPRL1 (B) and anti-RAGE antibodies. Localisation of FPR1, FPRL1 and RAGE/?RAGE was examined by double fluorescence microscopy. Bisbenzimide was used for nuclear counter-staining . The figures show representative results from one of three independent experiments, each performed in duplicate. Scale bar: 20? µm. The right columns show the resulting scatter plot of intensities across the two channels. The Pearson correlation coefficient rp and Spearman correlation coefficient rs are indicated on the scatter plots. For FPR1/FPRL1 (green channel) and RAGE/?RAGE (red channel), please note a good co-localisation.From: Slowik A, Merres J, Elfgen A, Jansen S, Mohr F, Wruck CJ, Pufe T, Brandenburg LO. Involvement of formyl peptide receptors in receptor for advanced glycation end products --and amyloid beta 1-42-induced signal transduction in glial cells. Mol Neurodegener. 2012 Nov 20;7:55.
  • IHC-P - Anti-Human RAGE Antibody (Serum) ABD11369
    Immunoperoxidase staining of formalin fixed, paraffin embedded porcine lung with Goat anti Human RAGE , bottom with no-antibody control, topImage courtesy of Prof. I. Spichal, Academy of Sciences of the Czech Republic, Novy Hradek
  • IHC - Anti-Human RAGE Antibody (Serum) ABD11369
    Immunoperoxidase staining of formalin fixed, paraffin embedded porcine small intestine with Goat anti Human RAGE , bottom with no-antibody control, topImage courtesy of Prof. I. Splichal, Academy of Sciences of the Czech Republic, Novy Hradek
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Func
Primary Accession Q15109
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 42803 Da
Additional Information
Other Species M,Rat,B,Chimpanzee,Dog,Pig
Purification Antisera to Human RAGE were raised by repeated immunisation of goats with highly purified antigen.
Immunogen Synthetic peptide, PKKPPQRLEWKLNTGRTE, corresponding to amino acids 42-59 of human RAGE.
Shelf Life 18 months from date of despatch.
Gene ID 177
Other Names Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER, RAGE
Target/Specificity Goat anti-Human RAGE antibody recognises the human Advanced glycosylation end product-specific receptor, also known as Receptor for Advanced Glycation End products (RAGE). RAGE is a 404 amino acid ~45 kDa single pass type 1 transmembrane glycoprotein bearing two Ig-like C2-type and a single Ig-like V-type domain. RAGE is a member of the Immunoglobulin superfamily which binds a variety of ligands including advanced glycation end products (AGEs) and amyloid fibrils. RAGE is expressed by endothelium, mononuclear phagocytes, smooth muscle and neurons. RAGE may be involved in a range of pathological conditions including diabetes (Ndipet al.2014) and Alzheimer's disease (Matroneet al.2014).
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human RAGE Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Schmidt, A.M. et al. (1996) RAGE: a novel cellular receptor for advanced glycation end products.
Diabetes. 45: S77 - 80. 2. Sugars, R. et al. (2007) Expression of HMGB1 during tooth development.
Cell Tissue Res 327: 511–9. 3. Rodríguez-Ayala, E. et al. (2005) Enhanced RAGE-mediated NFkappaB stimulation in inflamed hemodialysis patients.
Atherosclerosis. 180: 333-40. 4. Gomez, A. & Ferrer, I. (2010) Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.
Acta Neuropathol. 120: 155-67. 5. Aris, J.P. et al. (2010) Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats.
J Periodontol. 81: 1481-7. 6. Sugars, R. et al. (2007) Expression of HMGB1 during tooth development.
Cell Tissue Res. 327: 511-9. 7. Slowik, A. et al. (2012) Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells.
Mol Neurodegener. 7: 55. 8. Abdulahad, D. et al. (2013) High mobility group box1 (HMGB1) in relation to cutaneous inflammation in systemic lupus erythematosus (SLE).
Lupus. 22: 597-606. 9. Heilmann, .M. et al. (2014) Systemic levels of the anti-inflammatory decoy receptor soluble RAGE (receptor for advanced glycation end products) are decreased in dogs with inflammatory bowel disease.
Vet Immunol Immunopathol. 161: 184-92. 10. Khanna, S. et al. (2014) Excessive α-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke.
FASEB J. pii: fj.14-263723. 11. González-López, A. et al. (2012) MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.
PLoS One. 7(6):e39940. 12. Regan JK et al. (2015) Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep.
Reprod Sci. pii: 1933719115594014. 13. Ko, Y.H. et al. (2015) Methylprednisolone Protects Cardiac Pumping Mechanics from Deteriorating in Lipopolysaccharide-Treated Rats.
Front Physiol. 6: 348.

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