|Application ||WB, IHC-P|
|Calculated MW||26820 Da|
|Purification||Antisera to mouse Smac/DIABLO were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to amino acids 222-237 of mouse Smac/DIABLO.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, Smac, Diablo, Smac|
|Target/Specificity||Rabbit anti-Smac/Diablo antibody recognizes Diablo homolog, mitochondrial, also known as Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, Diablo or Smac. Smac is a 237 amino acid ~30 kDa mitochondrial protein bearing a 53 amino acid transit peptide at its N-terminus. Rabbit anti-Smac/Diablo antibody binds to the C-terminal region of murine Smac/DIABLO. Inhibitors of apoptosis proteins (IAP's) block cell death by caspase inhibition. X-linked inhibitor of apoptosis (XIAP) is a member of the IAP family. Smac/DIABLO is expressed in a variety of tissues and has been identified as a negative regulator of XIAP (Verhagen 2000).|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Smac/Diablo (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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