|Application ||WB, IHC-F, Func|
|Calculated MW||55628 Da|
|Purification||Antisera to human CYP2C9 were raised by repeated immunisation of rabbits with highly purified antigen.|
|Immunogen||Purified human CYP2C9 expressed in E.coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cytochrome P450 2C9, 1.14.13.-, (R)-limonene 6-monooxygenase, 18.104.22.168, (S)-limonene 6-monooxygenase, 22.214.171.124, (S)-limonene 7-monooxygenase, 126.96.36.199, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, S-mephenytoin 4-hydroxylase, CYP2C9, CYP2C10|
|Target/Specificity||Rabbit anti-Human Cytochrome P450 2C9 antibody recognizes human cytochrome p450 2C9 (CYP2C9). P450 enzymes are divided into two groups: steroidogenic and xenobiotic (Hornsbyet al.1989). The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism (Murrayet al.1992). Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members:CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.Rabbit anti-human cytochrome P450 2C9 is a neutralizing antibody which is a potent inhibitor of CYP2C9 activity. Inhibition of CYP2C19 activity has also been observed.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Human Cytochrome P450 2C9 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Ng, P.S. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.Drug Metab Pharmacokinet. 18 (3): 163-72. 2. Larsen, B.T. et al. (2006) Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.Am J Physiol Heart Circ Physiol. 290(2): H491-9. 3. Dai, D.P. et al. (2013) In vitro functional characterization of 37 CYP2C9 allelic isoforms found in Chinese Han population.Acta Pharmacol Sin. 34 (11): 1449-56. 4. Schmelzle, M. et al. (2011) Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).Prostaglandins Other Lipid Mediat. 94 (1-2): 25-33. 5. Guo, Y. et al. (2005) Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans.Drug Metab Dispos. 33: 749-53. 6. Dai, D.P. et al. (2014) CYP2C9 polymorphism analysis in Han Chinese populations: building the largest allele frequency database.Pharmacogenomics J. 14 (1): 85-92. 7. Schmidt, A. et al. (2011) Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.Toxicology. 281: 7-14. 8. Malaplate-Armand, C. et al. (2005) Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells.Toxicol Lett. 159: 203-11. 9. Guo, Y. et al. (2005) Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13.Xenobiotica. 35: 853-61.1. Werck-Reichhart, D. and Feyereisen, R. (2000) Protein family review Cytochromes P450: a success story.Genome Biology. 1: 1-9
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