|Application ||WB, Func|
|Calculated MW||57343 Da|
|Purification||Antisera to human CYP3A4 were raised by repeated immunisation of rabbits with highly purified antigen.|
|Immunogen||Purified human CYP3A4 expressed in E.Coli|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cytochrome P450 3A4, 1.14.13.-, 1, 8-cineole 2-exo-monooxygenase, 18.104.22.168, Albendazole monooxygenase, 22.214.171.124, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxygenase, 126.96.36.199, Taurochenodeoxycholate 6-alpha-hydroxylase, 188.8.131.52, CYP3A4, CYP3A3|
|Target/Specificity||ABD11378 recognises human cytochrome p450 3A4 (CYP3A4). P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members:CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1. ABD11378 is a neutralizing antibody which is a specific and potent inhibitor of CYP3A4.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Human Cytochrome P450 3A4 Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Vranová, I. et al. (2013) The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b5 and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and LungInt. J. Electrochem. Sci., 8 (2013) 1586 - 97 2. Ng, P.S. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.Drug Metab Pharmacokinet. 18 (3): 163-72. 3. Song, Z. et al. (2009) Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.Cell Res. 19: 1233-42. 4. Schmidt, A. et al. (2011) Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma.Toxicology. 281 (1-3): 7-14. 5. Hřebačková, J. et al. (2009) Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.Interdiscip Toxicol. 2: 205-10. 6. Poljaková, J. et al. (2013) Electrochemical Determination of Enzymes Metabolizing Ellipticine in Thyroid Cancer Cells - a Tool to Explain the Mechanism of Ellipticine Toxicity to these CellsInt. J. Electrochem. Sci. 8: 1573 - 85 7. Strick-Marchand, H. et al. (2015) A novel mouse model for stable engraftment of a human immune system and human hepatocytes.PLoS One. 10 (3): e0119820.1. Werck-Reichhart, D. & Feyereisen, R. (2000) Cytochromes P450: a success story.Genome Biol. 1 (6): REVIEWS3003.
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