|Calculated MW||126968 Da|
|Purification||Antisera to DDB1 (CT) were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide sequence DLIKVVEELTRIH corresponding to the C-terminal region of DDB1 (NP_001914).|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA damage-binding protein 1, DDB p127 subunit, DNA damage-binding protein a, DDBa, Damage-specific DNA-binding protein 1, HBV X-associated protein 1, XAP-1, UV-damaged DNA-binding factor, UV-damaged DNA-binding protein 1, UV-DDB 1, XPE-binding factor, XPE-BF, Xeroderma pigmentosum group E-complementing protein, XPCe, DDB1, XAP1|
|Target/Specificity||Goat anti-DDB1 antibody recognizes human DNA damage-binding protein 1, also known as DDB p127 subunit, DNA damage-binding protein a, Damage-specific DNA-binding protein 1, HBV X-associated protein 1, UV-damaged DNA-binding protein 1, XPE-binding factor or Xeroderma pigmentosum group E-complementing protein. DDB1 is an 1140 amino acid ~ kDA cytoplasmic protein that translocated to the nucleus following UV irradiation and subsequently accumulates at the site of DNA damage wjere it forms part of the UV-DDB complex and is involved in the nucleotide-excision repair of DNA following damage caused by ultraviolet radiation.Goat anti-DDB1 antibody binds to an epitope within the C-terminal (CT) region of damage-specific DNA binding protein 1.|
|Preservative & Stabilisers||0.02% Sodium Azide; 0.5% Bovine Serum Albumin;|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-DDB1 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Dualan, R. et al. (1995) Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.Genomics. 29: 62-69. 2. Nichols, A.F. et al. (2000) Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.J. Biol. Chem. 275: 21422-21428.
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