Anti-Human Amyloid Precursor Protein (C-Terminal) Antibody (Serum)
Rabbit Anti-Human Polyclonal Antibody
|Application ||WB, IHC-F, IP|
|Calculated MW||86943 Da|
|Purification||Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.|
|Immunogen||Synthetic peptide from C-terminus of APP.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1|
|Target/Specificity||ABD11391 recognises an epitope at the C-terminus of human amyloid precursor protein (APP).APP is a 110-130kD transmembrane protein. Processing of APP by Beta-secretase gives rise to amyloidogenic beta-amyloid proteins, deposition of which are characteristic of Alzheimer disease.APP exists in a number of isoforms. APP(695) is predominant in neuronal tissue, whilst APP(751) dominates elsewhere. APP also inhibits Notch signaling through it’s interaction with NUMB.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Amyloid Precursor Protein (C-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Lunemann, J.D.et al. (2007) Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis.Ann Neurol. 61: 476-83 2. Keller, C.W. et al. (2011) TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells.J Biol Chem. 286: 3970-80.
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