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Anti-Human Amyloid Precursor Protein (C-Terminal) Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05067
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 86943 Da
Additional Information
Other Species Pr
Purification Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.
Immunogen Synthetic peptide from C-terminus of APP.
Shelf Life 18 months from date of despatch.
Gene ID 351
Other Names Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1
Target/Specificity ABD11391 recognises an epitope at the C-terminus of human amyloid precursor protein (APP).APP is a 110-130kD transmembrane protein. Processing of APP by Beta-secretase gives rise to amyloidogenic beta-amyloid proteins, deposition of which are characteristic of Alzheimer disease.APP exists in a number of isoforms. APP(695) is predominant in neuronal tissue, whilst APP(751) dominates elsewhere. APP also inhibits Notch signaling through it’s interaction with NUMB.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Amyloid Precursor Protein (C-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Lunemann, al. (2007) Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis.
Ann Neurol. 61: 476-83 2. Keller, C.W. et al. (2011) TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells.
J Biol Chem. 286: 3970-80.

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Cat# ABD11391
(40 western blots)
Availability: Inquire
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