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Anti-Human Amyloid Precursor Protein (KPI Domain) Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05067
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 86943 Da
Additional Information
Other Species Pr
Purification Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.
Immunogen Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP.
Shelf Life 18 months from date of despatch.
Gene ID 351
Other Names Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1
Target/Specificity Rabbit anti-Human Amyloid Precursor Protein antibody recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of human amyloid precursor protein (APP).Only the APP-751 and APP-770 isoforms contain a KPI domain, it being absent from the APP-695 isoform that is most abundant in neuronal tissue. However, there is evidence that suggests KPI containing isoforms may be important in the pathogenesis of Alzheimer disease.Rabbit anti-Human Amyloid Precursor Protein antibody recognizes a band of ~115kDa in NTera2/DI cell lysates using western blotting under reducing conditions.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Amyloid Precursor Protein (KPI Domain) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Campbell, E. et al. (1999) Methods to uncover an antibody epitope in the KPI domain of Alzheimer's amyloid precursor protein for immunohistochemistry in human brain.
J. Neurosci. Methods 93: 133-138. 2. Jelic, V. et al. (2013) Abnormal Platelet Amyloid-ß Protein Precursor (AßPP) Metabolism in Alzheimer's Disease: Identification and Characterization of a New AßPP Isoform as Potential Biomarker
J Alzheimers Dis. 35: 285-95.

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Cat# ABD11393
(40 western blots)
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