Anti-Human Amyloid Precursor Protein (KPI Domain) Antibody (Serum)
Rabbit Anti-Human Polyclonal Antibody
|Application ||WB, IHC-P, IP|
|Calculated MW||86943 Da|
|Purification||Antisera to human APP were raised by repeated immunisations of rabbits with highly purified antigen.|
|Immunogen||Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1|
|Target/Specificity||Rabbit anti-Human Amyloid Precursor Protein antibody recognizes an epitope in the Kunitz protease inhibitor (KPI) domain of human amyloid precursor protein (APP).Only the APP-751 and APP-770 isoforms contain a KPI domain, it being absent from the APP-695 isoform that is most abundant in neuronal tissue. However, there is evidence that suggests KPI containing isoforms may be important in the pathogenesis of Alzheimer disease.Rabbit anti-Human Amyloid Precursor Protein antibody recognizes a band of ~115kDa in NTera2/DI cell lysates using western blotting under reducing conditions.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Amyloid Precursor Protein (KPI Domain) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Campbell, E. et al. (1999) Methods to uncover an antibody epitope in the KPI domain of Alzheimer's amyloid precursor protein for immunohistochemistry in human brain.J. Neurosci. Methods 93: 133-138. 2. Jelic, V. et al. (2013) Abnormal Platelet Amyloid-ß Protein Precursor (AßPP) Metabolism in Alzheimer's Disease: Identification and Characterization of a New AßPP Isoform as Potential BiomarkerJ Alzheimers Dis. 35: 285-95.
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