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Anti-Human Presenilin-1 (N-Terminal) Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49768
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 52668 Da
Additional Information
Other Species Ha,Pr
Purification Antisera to presenilin-1 were raised by repeated immunisations of rabbits with highly purified antigen.
Immunogen Synthetic peptide derived from N-terminus of human presenilin-1.
Shelf Life 18 months from date of despatch.
Gene ID 5663
Other Names Presenilin-1, PS-1, 3.4.23.-, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF12, PS1-CTF12, PSEN1, AD3, PS1, PSNL1
Target/Specificity ABD11394 recognises presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue.PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes. Mutations of presenilin-1 are associated with early onset Alzheimer's disease.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Presenilin-1 (N-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD11394
(40 western blots)
Availability: Inquire
Bulk Size
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