|Application ||WB, IHC-P, IHC-F, E|
|Calculated MW||86943 Da|
|Purification||Antisera to Beta amyloid (1-42) were raised by repeated immunisations of rabbits with highly purified antigen.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31, APP, A4, AD1|
|Target/Specificity||Rabbit anti-Human beta amyloid antibody recognises the beta amyloid (1-42) peptide, the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease (Benveniste et al. 2015). Beta amyloid also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy (Kirshner et al.2015).Rabbit anti-Human beta amyloid antibody (ABD11403) may be used in immunohistochemical staining of Alzheimer's disease plaques.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human beta Amyloid (aa1-42) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Bertrand, E. et al (2008) Amyloid angiopathy in idiopathic Parkinson's disease. Immunohistochemical and ultrastructural study.Folia Neuropathologica. 46: 255-269. 2. Carty, N.C. et al. (2006) Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice.J Neuroinflammation. 3: 11. 3. Jeffrey, M. et al. (2014) Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aß and mutated human APP.Neuropathol Appl Neurobiol. Aug 18. [Epub ahead of print]
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