|Application ||WB, E|
|Calculated MW||14646 Da|
|Purification||Antisera to human Exodus-2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant human Exodus-2|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-C motif chemokine 21, 6Ckine, Beta-chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21, CCL21, SCYA21|
|Target/Specificity||Rabbit anti-Human Exodus-2 antibody recognizes human Exodus-2, otherwise known as CCL21, a 111 amino acid CC chemokine which, like CCL19 (small inducible cytokine A19), signals through the CCR7 receptor.Exodus-2 is expressed in the HEV and T cell rich areas of lymph nodes and Peyer’s patches, T cell areas of the spleen and by lymphatic endothelium of many organs, acting as a potent chemoattractant for thymocytes and T lymphocytes. Exodus-2 possesses characteristics of a homing molecule for lymphocytes to secondary lymphoid organs and has been shown to inhibit haematopoiesis.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Exodus-2 Antibody (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Hromas, R. et al. (1997) Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J. Immunol. 159: 2554-2558. 2. Gunn, M.D. et al. (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naïve T lymphocytes. Proc Natl Acad Sci U S A. 95: 258-263.
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