|Application ||WB, E|
|Calculated MW||10085 Da|
|Purification||Antisera to human MIP-1 alpha were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human MIP-1 alpha.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein, MIP-1-alpha(4-69), LD78-alpha(4-69), CCL3, G0S19-1, MIP1A, SCYA3|
|Target/Specificity||Goat anti-Human MIP-1 alpha antibody recognizes human MIP-1 alpha, otherwise known as CCL3, a 69 amino acid member of the CC chemokine family which plays a critical role in haematopoiesis and is shown to signal through the chemokine receptors CCR1, CCR4 and CCR5.MIP-1 alpha is also involved in host defence against invading pathogens, acting as a regulator of activation and trafficking of inflammatory cells, such as macrophages, NK cells, granulocytes, dendritic cells and CD8+ lymphocytes. The recruitment of inflammatory cells by MIP-1 alpha, has been linked with the pathogenesis of several diseases, including rheumatoid arthritis, H. pylori associated gastritis and bacterial meningitis.The secretion of MIP-1 alpha by CD8+ lymphocytes acts as a major HIV-suppressive factor (HIV-SF) through binding to CCR5, identified as a coreceptor for HIV-1 target cell entry.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human MIP-1 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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