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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human PDGF AA Homodimer Antibody    

Anti-Human PDGF AA Homodimer Antibody

Rabbit Anti-Human Polyclonal Antibody

     
  • IHC - Anti-Human PDGF AA Homodimer Antibody  ABD11428
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-AA following enzyme mediated antigen retrieval using proteinase K
  • IHC-P - Anti-Human PDGF AA Homodimer Antibody  ABD11428
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-AA following enzyme mediated antigen retrieval using proteinase K
  • IHC-P - Anti-Human PDGF AA Homodimer Antibody  ABD11428
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-AA following enzyme mediated antigen retrieval using proteinase K
  • IHC-P - Anti-Human PDGF AA Homodimer Antibody  ABD11428
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-AA following enzyme mediated antigen retrieval using proteinase K
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Func
Primary Accession P04085
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 24043 Da
Additional Information
Purification Antisera to human PDGF-AA were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human PDGF-AA.
Shelf Life 12 months from date of reconstitution.
Gene ID 5154
Other Names Platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide, PDGFA, PDGF1
Target/Specificity Rabbit anti-Human PDGF AA Homodimer antibody recognizes human PDGF-AA (Platelet derived growth factor A chain), a disulphide-linked alpha-chain homodimer and member of the PDGF family, released from platelet alpha-granules following trauma/platelet activation.Naturally occurring active forms of PDGF exist as dimers of two alpha chains (AA), two beta chains (BB), or a combination of both chains (AB), all of which signal through the high-affinity PDGF-Ralpha receptor, and the latter two of which can also signal through the PDGF-Rbeta receptor. PDGFs are potent mitogens for a variety of cells including those of the connective tissue, bone and cartilage, blood and smooth muscle cells, and are involved in several biological processes including chemotaxis, hyperplasia and embryonic neurogenesis.Increased expression of PDGF-AA has been associated with a diverse range of conditions including progression of osteosarcomas, persistent Cytomegalovirus infection in kidney allografts and mediation of IL-13-stimulated lung fibroblast proliferation in asthma.
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Human PDGF AA Homodimer Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Rorsman, F. et al. (1998) Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: Alternative exon usage predicts two different precursor proteins.
Mol. Cell. Biol. 8: 571-577.2. Ingram, J.L. et al. (2004) IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha.
FASEB J. 18: 1132-1134.

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Cat# ABD11428
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