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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human PDGF BB Homodimer Antibody    

Anti-Human PDGF BB Homodimer Antibody

Rabbit Anti-Human Polyclonal Antibody

     
  • IHC - Anti-Human PDGF BB Homodimer Antibody  ABD11429
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-BB folowing enzyme mediated antigen retrieval using proteinase K
  • IHC-P - Anti-Human PDGF BB Homodimer Antibody  ABD11429
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-BB folowing enzyme mediated antigen retrieval using proteinase K
  • IHC-P - Anti-Human PDGF BB Homodimer Antibody  ABD11429
    Formalin fixed, paraffin embedded human skin stained with Rabbit anti Human PDGF-BB folowing enzyme mediated antigen retrieval using proteinase K
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Func
Primary Accession P01127
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 27283 Da
Additional Information
Purification Antisera to human PDGF-BB were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human PDGF-BB
Shelf Life 12 months from date of reconstitution.
Gene ID 5155
Other Names Platelet-derived growth factor subunit B, PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin, PDGFB, PDGF2, SIS
Target/Specificity Rabbit anti-Human PDGF BB Homodimer antibody recognizes human PDGF-BB (Platelet derived growth factor B chain), a disulphide-linked beta-chain homodimer and member of the PDGF family, released from platelet alpha-granules following trauma/platelet activation.Naturally occurring active forms of PDGF exist as dimers of two alpha chains (AA), two beta chains (BB), or a combination of both chains (AB), all of which signal through the high-affinity PDGF-Ralpha receptor, and the latter two of which can also signal through the PDGF-Rbeta receptor. PDGFs are potent mitogens for a variety of cells including those of the connective tissue, bone and cartilage, blood and smooth muscle cells, and are involved in several biological processes including chemotaxis, hyperplasia and embryonic neurogenesis.The expression of PDGF-BB is associated with autocrine growth stimulation and the formation of various tumour types, with several studies focusing on dermatofibrosarcoma protuberans (DP), an infiltrating skin tumour arising from a translocation occurring between chromosome 22 (the location of the PDGFB gene) and chromosome 17 (the location of the COL1A1 gene), which results in the generation of the COL1A1-PDGFB chimeric protein.
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Human PDGF BB Homodimer Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Rao, C.D. et al. (1986) Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.
Proc Natl Acad Sci U S A83: 2392-2396.2. Simon, M-P. et al. (2001) Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in dermatofibrosarcoma protuberans (DP).
Oncogene 20: 2965-2975.

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Cat# ABD11429
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