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Anti-Human Histone H2AX Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human Histone H2AX Antibody  ABD11438
    Detection of human and mouse histone H2AX in nuclear extracts from human 293T, human G-361 and wild type (+/+) or H2AX knockout (-/-) mouse embryonic fibroblasts by Western blotting using Rabbit anti Human H2AX
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16104
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 15145 Da
Additional Information
Purification Antisera to human H2AX were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to a region within the C-terminus of human H2AX (locus link ID 3014)
Shelf Life 18 months from date of despatch.
Gene ID 3014
Other Names Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX
Target/Specificity Rabbit anti-Human Histone 2AX antibody recognizes human histone 2AX (H2AX), a 143 amino acid, ~15kDa member of the histone H2A family differing from other members in having a unique carboxy-terminal region containing a conserved serine, four bases from the carboxy terminus (Redon 2002) which becomes rapidly phosphorylated following DNA double stranded breaks (Rogakouet al.1998).H2AX is involved in DNA repair and the maintenance of genomic stability, although its precise role is still to be defined. H2AX is phosphorylated soon after the appearance of double-stranded breaks, and has been implicated both in homologous recombination and non-homologous end joining DNA repair pathways. H2AX is thought to have a critical function in the recruitment of DNA repair factors and DNA damage-signaling proteins (Scully and Xie 2013). Phoshorylation of H2AX is linked to DNA fragmentation during apoptosis (Rogakuet al.2000).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human Histone H2AX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD11438
(40 western blots)
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