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Anti-Human MCM6 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human MCM6 Antibody  ABD11440
    Detection of human MCM6 in a RIPA extract of HeLa cells by Western Blotting using Rabbit anti Human MCM6
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14566
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 92889 Da
Additional Information
Purification Antisera to human MCM6 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to a region within human MCM6 (locus link ID 4175)
Shelf Life 18 months from date of despatch.
Gene ID 4175
Other Names DNA replication licensing factor MCM6,, p105MCM, MCM6
Target/Specificity Rabbit anti-Human MCM6 antibody recognizes human DNA replication licensing factor MCM6, also known as minichromosome maintenance 6 (MCM6) or p105MCM. MCM6 is a 821 amino acid, ~115kDa nuclear component of the MCM complex containing a single MCMdomain.MCM6 is involved in the initiation and control of eukaryotic DNA replication. Studies show that MCM4 forms a hexameric protein complex with MCM6 and 7, which has DNA helicase activity, and may act as a DNA unwinding enzyme (Kanteret al.2008). The phosphorylation of this complex by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex (Ishimiet al.2001).MCM6 has been noted to have elevated expression in Hodgkin's lymphoma (Karimiet al.2008) and be a predictor of survival in patients with mantle cel lymphoma (Schraderet al.2005).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human MCM6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD11440
(40 western blots)
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