|Calculated MW||92889 Da|
|Purification||Antisera to human MCM6 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within human MCM6 (locus link ID 4175)|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA replication licensing factor MCM6, 184.108.40.206, p105MCM, MCM6|
|Target/Specificity||Rabbit anti-Human MCM6 antibody recognizes human DNA replication licensing factor MCM6, also known as minichromosome maintenance 6 (MCM6) or p105MCM. MCM6 is a 821 amino acid, ~115kDa nuclear component of the MCM complex containing a single MCMdomain.MCM6 is involved in the initiation and control of eukaryotic DNA replication. Studies show that MCM4 forms a hexameric protein complex with MCM6 and 7, which has DNA helicase activity, and may act as a DNA unwinding enzyme (Kanteret al.2008). The phosphorylation of this complex by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex (Ishimiet al.2001).MCM6 has been noted to have elevated expression in Hodgkin's lymphoma (Karimiet al.2008) and be a predictor of survival in patients with mantle cel lymphoma (Schraderet al.2005).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human MCM6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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