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Anti-Human NBS1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human NBS1 Antibody  ABD11441
    Detection of human NBS1 in nuclear extracts from HeLa cells and 293T cells by Western blotting and from HeLa cells by immunoprecipitation with Rabbit anti Human NBS1 NBS1 was also immunoprecipitated with an antibody directed to an alternate regoin of the molecule
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60934
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 84959 Da
Additional Information
Purification Antisera to human NBS1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to a region within human NBS1 (locus link ID 4683)
Shelf Life 12 months from date of reconstitution.
Gene ID 4683
Other Names Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, NBN, NBS, NBS1, P95
Target/Specificity Rabbit anti-Human NBS1 antibody recognizes human Nijmegen breakage syndrome 1, also known as nibrin, NBS1 or Cell cycle regulatory protein p95.NBS1 interacts with MRE11 and RAD50 to form a complex with nuclease activity which is involved in the initiation of nonhomologous end joining and homologous recombination. It is thought that NBS1 is involved in both DNA double-strand break repair and DNA damage-induced checkpoint activation (Varonet al.1998).Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by hypersensitivity to ionizing radiation and cancer predisposition (Varonet al.1998).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human NBS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD11441
(40 western blots)
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