|Application ||WB, IP|
|Calculated MW||84959 Da|
|Purification||Antisera to human NBS1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within human NBS1 (locus link ID 4683)|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, NBN, NBS, NBS1, P95|
|Target/Specificity||Rabbit anti-Human NBS1 antibody recognizes human Nijmegen breakage syndrome 1, also known as nibrin, NBS1 or Cell cycle regulatory protein p95.NBS1 interacts with MRE11 and RAD50 to form a complex with nuclease activity which is involved in the initiation of nonhomologous end joining and homologous recombination. It is thought that NBS1 is involved in both DNA double-strand break repair and DNA damage-induced checkpoint activation (Varonet al.1998).Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by hypersensitivity to ionizing radiation and cancer predisposition (Varonet al.1998).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human NBS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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