|Calculated MW||80593 Da|
|Purification||Antisera to human MRE11 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within the N-terminal region of human MRE11 (locus link ID 4361)|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11A, HNGS1, MRE11|
|Target/Specificity||Rabbit anti-human MRE11 antibody recognizes human meiotic recombination 11 (MRE11), also known as Double-strand break repair protein MRE11A or ATLD. MRE11 is a 708 amino acid nuclear protein component of the MRN complex (van den Bosch et al.2003) which is involved in homologous recombination, telomere length maintenance through interaction with LSD1(Porroet al.2014) and DNA double-strand break repair (Shibataet al.2014). MRE11 has 3' to 5' exonuclease activity and endonuclease activity (Paullet al.1998).Mutations in this gene are associated with Ataxia telangiectasia-like disorder, which is characterized by hypersensitivity to ionizing radiation and defective checkpoint responses (Petriniet al.2000).|
|Preservative & Stabilisers||0.1% Sodium Azide|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human MRE11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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