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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti-Human SMC1 (pSer957) Antibody    

Anti-Human SMC1 (pSer957) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Human SMC1 (pSer957) Antibody  ABD11445
    Detection of human phospho-SMC1 in whole cell lysates from HeLa cells subjected to 10Gy gamma irradiation or mock irradiated. Lysate was subsequently treated with calf alkaline phosphatase (CIP) of left untreated as indicated by Western Blotting with Rabbit anti phospho-SMC1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14683
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 143233 Da
Additional Information
Purification Antisera to human phosphorylated SMC1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Phosphorylated synthetic peptide corresponding to a region within human SMC1 (locus link ID 5884) around serine 957.
Shelf Life 18 months from date of despatch.
Gene ID 8243
Other Names Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb1.8, SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1
Target/Specificity Rabbit anti-Human SMC1 antibody recognizes human structural maintenance of chromosomes-1 (SMC1) which is phosphorylated at Ser957.SMC1 forms a heterodimer with SMC3, and is involved in sister chromatid cohesion and in DNA recombination and repair. SMC1 can be phosphorylated by ATM on serines 957 and 966 in vitroandin vivo in response to ionizing radiation (Kimet al.2002). SMC1 also acts as a downstream effector in the ATM/NBS1 pathway of S-phase checkpoint (Yazdiet al.2002).
Preservative & Stabilisers 0.1% Sodium Azide (NaN3)
Storage Store at +4℃. DO NOT FREEZE.
PrecautionsAnti-Human SMC1 (pSer957) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Kim, S.T. et al. (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.
Genes Dev. 16(5):560-70.

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Cat# ABD11445
(40 western blots)
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