|Application ||WB, IP|
|Calculated MW||143233 Da|
|Purification||Antisera to human phosphorylated SMC1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Phosphorylated synthetic peptide corresponding to a region within human SMC1 (locus link ID 5884) around serine 957.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb1.8, SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1|
|Target/Specificity||Rabbit anti-Human SMC1 antibody recognizes human structural maintenance of chromosomes-1 (SMC1) which is phosphorylated at Ser957.SMC1 forms a heterodimer with SMC3, and is involved in sister chromatid cohesion and in DNA recombination and repair. SMC1 can be phosphorylated by ATM on serines 957 and 966 in vitroandin vivo in response to ionizing radiation (Kimet al.2002). SMC1 also acts as a downstream effector in the ATM/NBS1 pathway of S-phase checkpoint (Yazdiet al.2002).|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human SMC1 (pSer957) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kim, S.T. et al. (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.Genes Dev. 16(5):560-70.
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