|Calculated MW||12580 Da|
|Purification||Antisera to human 4EBP1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within human 4EBP1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1|
|Target/Specificity||ABD11450 is specific for human eukaryotic translation initiation factor 4E binding protein 1 (4EBP1). 4EBP1 is principally expressed in the cytoplasm, and has a role in translation regulation. 4EBP1 binds to eukaryotic translation initiation factor 4E (eIF4E), which prevents the formation of the active eIF4E complex. Hyperphosphorylation of 4EBP1 results in the release of eIF4E, thus allowing the translation complex to assemble.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-4EBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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