|Calculated MW||45144 Da|
|Purification||Antisera to human CKII alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region of human CKII alpha encoded within exon 3.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Casein kinase II subunit alpha, CK II alpha, 184.108.40.206, CSNK2A1, CK2A1|
|Target/Specificity||Rabbit anti-Human Casein Kinase 2 alpha antibody recognizes human casein kinase II alpha, also known as CKIIa or Casein kinase II subunit alpha. CKIIa is a 391 amino acid ~42 kDa protein which localises to the endoplasmic reticulum and Golgi apparatus. CKII is ubiquitous composed of three subunits (alpha, alpha prime and beta) which form a tetrameric holoenzyme with 2 alpha, alpha' subunits or one of each together with two beta subunits (Lozemanet al1990). The alpha and alpha prime subunits are catalytic whilst the beta subunit appears to have a regulatory role (Ermakovaet al.2003).CKII is involved in the regulation of numerous pathways, including signal transduction, cell cycle and some metabolic pathways|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Casein Kinase 2 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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