|Application ||WB, IF|
|Calculated MW||15145 Da|
|Purification||Antisera to human H2AX were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within the C-terminus of human H2AX.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX|
|Target/Specificity||Rabbit anti-Human Histone H2AX antibody recognizes human histone H2AX.H2AX comprises approximately 2-25% of the histone H2A pool in mammalian cells. The extended C-terminal tail of H2AX contains a serine (Ser139) embedded in an conserved SQE motif, which is rapidly phosphorylated at sites of double strand breaks and stalled replication forks. Phosphorylated H2AX may serve to recruit other repair proteins to the site of DNA damage.H2AX has been implicated in both homologous recombination and nonhomologous end joining DNA repair pathways.|
|Preservative & Stabilisers||0.1% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Histone H2AX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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