|Calculated MW||40556 Da|
|Purification||Antisera to human RFC3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within human RFC3.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Replication factor C subunit 3, Activator 1 38 kDa subunit, A1 38 kDa subunit, Activator 1 subunit 3, Replication factor C 38 kDa subunit, RF-C 38 kDa subunit, RFC38, RFC3|
|Target/Specificity||Rabbit anti-Human RFC3 antibody recognizes human Replication factor C subunit 3, also known as RFC3, Activator 1 38 kDa subunit, Replication factor C 38 kDa subunit or RFC38. RFC3 is a 356 amino acid ~38 kDa DNA binding protein found in several protein complexes critical for DNA replication and repair. Replication factor C (RFC) is a heteropentameric complex consisting of one large subunit, RFC1, and four small subunits, RFC2, RFC3, RFC4 and RFC5. This complex is required for efficient loading of PCNA onto DNA templates during processive DNA synthesis.A second RFC-related related complex is formed from interactions between Rad24, RFC2, RFC3, RFC4 and RFC5. This complex serves to load the heterotrimeric DNA damage checkpoint clamp (consisting of Rad17, Mec3, and Ddc1) onto partial duplex DNA in an ATP-dependent manner.The DNA damage checkpoint response arrests cells at appropriate points in the cell cycle to allow recovery of the integrity of the DNA before re-entering the cell cycle.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human RFC3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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