|Calculated MW||155293 Da|
|Purification||Antisera to human SRC3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a region within human SRC3 encoded by exon 16.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Nuclear receptor coactivator 3, NCoA-3, 22.214.171.124, ACTR, Amplified in breast cancer 1 protein, AIB-1, CBP-interacting protein, pCIP, Class E basic helix-loop-helix protein 42, bHLHe42, Receptor-associated coactivator 3, RAC-3, Steroid receptor coactivator protein 3, SRC-3, Thyroid hormone receptor activator molecule 1, TRAM-1, NCOA3, AIB1, BHLHE42, RAC3, TRAM1|
|Target/Specificity||Rabbit anti-Human SRC3 antibody recognizes human nuclear receptor coactivator 3, also known as SRC3, NCoA3, Amplified in breast cancer 1 protein, AIB1, CBP-interacting protein, Class E basic helix-loop-helix protein 42, Receptor-associated coactivator 3. Steroid receptor coactivator protein 3 or Thyroid hormone receptor activator molecule 1. SRC3 is a 1423 amino acid ~160 kDa member of the steroid receptor coactivator family members which interact with nuclear receptors and enhance the transcription of target genes in a ligand-dependent manner. SRC3 has been shown to interact with several steroid receptors, such as oestrogen receptor alpha and progesterone receptor. Altered expression of SRC3 has been reported in a number of cancers, including breast cancer (Osborneet al.2003). In addition, SRC3 interacts with IKK, suggesting that SRC3 may be involved in inflammatory and immune responses mediated by NF-kappaB (Wuet al.2002).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃. DO NOT FREEZE.|
|Precautions||Anti-Human SRC3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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