|Application ||WB, IP|
|Calculated MW||94135 Da|
|Purification||Antisera to human STAT6 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to a 40 amino acid sequence within human STAT6.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Signal transducer and activator of transcription 6, IL-4 Stat, STAT6|
|Target/Specificity||Rabbit anti-STAT6 antibody recognizes human signal transducer and activator of transcription 6, also known as STAT6 or IL-4 STAT. STAT6 is a 846 amino acid ~100 kDa, latent cytosolic transcription factor which becomes activated following phosphorylation by JAK1 and JAK3, in response to IL-4 and IL-13. Upon activation, STAT6 proteins form homodimers which translocate to the nucleus. STAT6 is critical for the expression of many IL-4 and IL-13 responsive genes, including class II major histocompatibility molecules, CD23 and IL-1Ra. It also plays an important role in Th2 differentiation, IgE class switching and inflammation.Binding of Rabbit anti-STAT6 antibody can be blocked by the control peptide BLP076.|
|Preservative & Stabilisers||0.1% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-STAT6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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