|Calculated MW||36633 Da|
|Purification||Antisera to phosphorylated rat CREB were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within CREB which includes phosphorylated Ser133.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, Creb1, Creb-1|
|Target/Specificity||Rabbit anti-phosphorylated CREB antibody recognizes rat cyclic AMP response element binding protein 1, also known as CREB or CREB-1, when phosphorylated at serine 133.CREB is a member of the leucine zipper family of transcription factors, which is involved in a wide range of intracellular signalling processes.Phosphorylation of serine 133 has been demonstrated by several protein kinases, including protein kinase A (PKA), mitogen activated protein kinase (MAPK) and Ca2+ /calmodulin-dependent protein kinase (CaMK). This phophorylation is required for CREB mediated transcription.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-CREB (pSer133) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Mayr, B.M. et al. (2001) Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB.Proc Natl Acad Sci U S A. 98 (19): 10936-41.
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