|Calculated MW||44888 Da|
|Purification||Antisera to phosphorylated ELK-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within ELK-1 which includes phosphorylated Ser383.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||ETS domain-containing protein Elk-1, ELK1|
|Target/Specificity||Rabbit anti-phosphorylated ELK-1 antibody recognizes rat ETS domain-containing protein Elk-1 (ELK-1) when phosphorylated at serine 383.ELK-1 is a member of the ternary complex factor (TCF) family of transcription factors, which is thought to play a role in mediating gene expression in response to growth factors. ELK-1 can be phosphorylated at serine 383 and 389 in its C-terminal region in response to the activation of extracellular signal-regulated kinase (ERK) proteins. Phosphorylation of ELK-1 results in an increase in its transcriptional activity, leading to the transcription of growth-related proteins, such as c-Fos.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-ELK-1 (pSer383) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Yang, S. et al. (1998) The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.Mol. Cell. Biol. 18: 710 - 720.
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