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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Amyotrophic Lateral Sclerosis (ALS)   >   Anti-p38 MAPK (pThr180/Tyr182) Antibody    

Anti-p38 MAPK (pThr180/Tyr182) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-p38 MAPK (pThr180/Tyr182) Antibody  ABD11477
    Published customer image:Rabbit anti p38 MAPK (pThr180/Tyr182) used for western blotting of newt (Notophthalmus viridescens) mesemchymal derived A1 cell extracts.Image captionActivation of JNK, p38 and c-Fos during myotube S-phase reentry (A, C) Western blot analysis of A1 myotube extracts pre (0.25%FCS) or at different times post induction with 10%FCS. ERK indicates treatment with an ERK inhibitor, JNK/p38 denote treatment with either a JNK or p38 inhibitor respectively. Treatments were initiated at 0h post induction. (B) Western blot analysis of A1 myotube extracts 1 hour post serum induction, treated with the indicated inhibitors. Note that the ERK inhibitor specifically abrogates ERK phosphorylation. Inhibition of BMK1/ERK5 promotes S phase re-entry by decreasing A1 mononucleate proliferation (D) Western blot analysis of A1 myotube extracts pre (0.25%FCS) or 1 hour post serum induction. (E)Representative image of A1 myotubes after 2d in high serum stained with antibodies against p-RBS807/811, MyHC and Hoechst 33258. (F) Representative image of A1 myotubes at 3d post-induction in high serum following a BrdU pulse. Myotubes were stained with antibodies against BrdU and Hoechst 33258. (G,H) Quantification of BrdU positive mononucleate cells (G) or combined cultures (H), as measured by immunostaining at 72h post serum induction following a BrdU pulse. Cells were treated with the indicated compounds. In (H), myotubes were induced and 30% confluent A1 proliferating cells were added where indicated . All values represent the mean ± s.e.m (*p
  • WB - Anti-p38 MAPK (pThr180/Tyr182) Antibody  ABD11477
    Western blot of HeLa cell lysate that had been treated with +/- UV (30 min) showing phosphospecific immunolabeling of the ~39 kDa p38 MAPK protein phosphorylated at Thr180 and Tyr182
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P70618
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 41321 Da
Additional Information
Other Species C,Zf,H,B,Pr,M,Dog,Newt
Purification Antisera to phosphorylated rat p38 MAPK were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within p38 MAPK which includes phosphorylated Thr180 and Tyr182.
Shelf Life 12 months from date of reconstitution.
Other Names Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14,, CRK1, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Mapk14, Csbp1, Csbp2
Target/Specificity Rabbit anti-p38MAPK (pThr180/tyr182 antibody recognizes p38 mitogen-activated protein kinase (p38 MAPK), also known as MAPK14, when phosphorylated at threonine 180 and tyrosine 182.p38 MAPK is a serine/threonine kinase which plays an important role in signal transduction, contributing to the regulation of many cellular processes including cell differentiation and inflammation.p38MAPK is activated by phosphorylation of threonine 180 and tyrosine 182, by several upstream kinases, in response to a wide range of extracellular stimuli such as UV B irradiation or endotoxin exposure.
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-p38 MAPK (pThr180/Tyr182) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Yun, M.H. et al. (2014) Sustained ERK activation underlies reprogramming in regeneration-competent salamander cells and distinguishes them from their mammalian counterparts.
Stem Cell Reports. 3: 15-23. 2. Suzuki, K. and Namiki, H. (2012) Restraint of spreading-dependent activation of polymorphonuclear leukocyte NADPH oxidase in an acidified environment.
J Cell Biochem. 113: 899-910.1. Raingeaud, J. et al. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
J. Biol. Chem. 270: 7420-7426.

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Cat# ABD11477
(40 western blots)
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