|Calculated MW||73988 Da|
|Purification||Antisera to phosphorylated synapsin I were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within Synapsin I which includes the phosphorylated residue Ser9.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Synapsin-1, Synapsin I, Syn1|
|Target/Specificity||Rabbit anti-phosphorylated Synapsin I antibody recognizes rat Synapsin I, when phosphorylated at serine 9.Synapsin I is a neuron-specific phosphoprotein which is associated with synaptic vesicles in the central and peripheral nervous system and is involved in the regulation of synaptic vesicle availability, and thought to play a key role in brain plasticity.Synapsin I is phosphorylated at serine 9 by cAMP-dependent protein kinase and calcium calmodulin kinase I.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Synapsin I (pSer9) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Jovanovic, J.N. et al. (2001) Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+ -dependent glutamate release in isolated nerve terminals.J. Neurosci. 21: 7944 - 7953. 2. Kao, H.T. et al. (2002) A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth.Nature Neurosci. 5: 431 - 437. 3. Menegon, A. et al. (2000) Use of phosphosynapsin I-specific antibodies for image analysis of signal transduction in single nerve terminals.J. Cell Sci. 113: 3573 - 3582.
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