|Calculated MW||50671 Da|
|Purification||Ig fraction prepared by ammonium sulphate precipitation|
|Immunogen||Fusion protein corresponding to amino acids 171-356 of human BLNK|
|Shelf Life||18 months from date of despatch.|
|Other Names||B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Lymphocyte antigen 57, Src homology 2 domain-containing leukocyte protein of 65 kDa, Slp-65, Blnk, Bash, Ly57, Slp65|
|Target/Specificity||Rabbit anti-BLNK antibody recognizes B-cell Linker Protein, also known as BLNK or SLP-65, a cytosolic adaptor molecule functioning as a central linker protein linking the SYK kinase to a variety of signalling pathways.The resulting tyrosine phosphorylation of BLNK by syk, provides docking sites for the SH2-containing effector molecules such as Vav, PLC gamma and the adaptor proteins Crb2 and Nck.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse BLNK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Fu, C. et al. (1998) BLNK: a central linker protein in B cell activation.Immunity 9(1): 93-103.2. Xu, S. et al. (2000) B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice.Int. Immunol. 12(3): 397-404.3. Chiu, C.W.et al. (2002) BLNK: molecular scaffolding through ‘cis’-mediated organization of signaling proteins.EMBO J. 21: 6461-6472.
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