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Anti-GluR1 (pSer845) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-GluR1 (pSer845) Antibody  ABD11486
    Western blot of rat hippocampal lysate showing phosphospecific immunolabeling of the ~100 kDa GluR1 protein phosphorylated at Ser845
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19490
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 101579 Da
Additional Information
Purification Antisera to phosphorylated GluR1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within rat GluR1 which includes the phosphorylated residue Ser845.
Shelf Life 12 months from date of reconstitution.
Gene ID 50592
Other Names Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, Gria1, Glur1
Target/Specificity Rabbit anti-phosphorylated GluR1 antibody recognizes rat glutamate receptor subunit 1 (GluR1) when phosphorylated at serine 845. GluR1, widely expressed throughout the nervous system, is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses. Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-GluR1 (pSer845) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Castellani, G.C. et al. (2001) A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors.
Proc. Natl. Acad. Sci. USA. 98: 12772 - 12777.

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Cat# ABD11486
(40 western blots)
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