|Calculated MW||51118 Da|
|Purification||Antisera to phosphorylated tryptophan hydroxylase were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within Tryptophan Hydroxylase which includes the phosphorylated residue Ser58.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Tryptophan 5-hydroxylase 1, 22.214.171.124, Tryptophan 5-monooxygenase 1, TPH1, TPH|
|Target/Specificity||Rabbit anti-phosphorylated tryptophan hydroxylase antibody recognizes tryptophan hydroxylase (TPH), when phosphorylated at serine 58.TPH catalyses the 5-hydroxylation of tryptophan, in the first stage in indolamine biosynthesis (e.g. serotonin and melatonin). The activity of TPH is enhanced by phosphorylation of Ser58, by cAMP dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAMKII).|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Tryptophan Hydroxylase (pSer58) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Banik, U. et al. (1997) Interaction of phosphorylated tryptophan hydroxylase with 14-3-3 proteins.J. Biol. Chem. 272: 26219 - 26225.
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