|Calculated MW||51754 Da|
|Purification||Antisera to rat GABAA receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Fusion protein within the cytoplasmic loop of rat GABAA receptor alpha 1 subunit.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, Gabra1, Gabra-1|
|Target/Specificity||Rabbit anti-GABA A Receptor alpha 1 antibody recognizes the alpha 1 subunit of gamma-aminobutyric acid A (GABAA) receptor.GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell.GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-GABA A Receptor alpha 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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