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Anti-GABA A Receptor alpha 4 (C-Terminal) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti-GABA A Receptor alpha 4 (C-Terminal) Antibody  ABD11490
    Western blot of rat hippocampal lysate showing specific immunolabelling of the ~64 kDa -alpha 4 of the of the GABA alpha-R
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28471
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 60951 Da
Additional Information
Other Species H,B,M
Purification Antisera to GABAA receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to the C-Terminal region of the alpha 4 subunit of rat GABAA receptor coupled to KLH.
Shelf Life 18 months from date of despatch.
Gene ID 140675
Other Names Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4, Gabra4
Target/Specificity ABD11490 is specific for the alpha 4 subunit of rat gamma-aminobutyric acid A (GABAA ) receptor. GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell.GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).
Preservative & Stabilisers 0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-GABA A Receptor alpha 4 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Burt, D.R. et al. (1991) GABAA receptor subtypes: from pharmacology to molecular biology.
FASEB. J, 5: 2916-2923.

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Cat# ABD11490
(40 western blots)
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