|Calculated MW||60951 Da|
|Purification||Antisera to GABAA receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to the C-Terminal region of the alpha 4 subunit of rat GABAA receptor coupled to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4, Gabra4|
|Target/Specificity||ABD11490 is specific for the alpha 4 subunit of rat gamma-aminobutyric acid A (GABAA ) receptor. GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell.GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.01% Bovine Serum Albumin; 50% Glycerol|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-GABA A Receptor alpha 4 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Burt, D.R. et al. (1991) GABAA receptor subtypes: from pharmacology to molecular biology.FASEB. J, 5: 2916-2923.
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