|Application ||WB, E, Func|
|Purification||Antisera to chicken Interleukin-1β were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G|
|Immunogen||Recombinant chicken IL-1β|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||ABD11502 recognizes chicken Interleukin 1 beta (chIL-1beta), which shares homology with mammalian IL-1beta.IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression.Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.ABD11502 neutralizes chicken IL-1 beta (1-2).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Chicken Interleukin-1 beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Gyorfy, Z. et al. (2003) Truncated chicken interleukin-1beta with increased biologic activity.J. Interferon and Cytokine Research 23: 223-228. 2. De Boever, S. et al. (2010) Flow cytometric differentiation of avian leukocytes and analysis of their intracellular cytokine expression.Avian Pathol. 39: 41-6.1. Staeheli, P. et al. (2001) Cytokines of Birds: Conserved functions – A largely different look.J. Interferon and Cytokine Research 21: 993-1010.2. Weining, K.C. et al. (1998) A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein.Eur. J. Biochem. 258: 994-1000.3. Bombara, C.J. et al. (1991) Signal transduction events in chicken interleukin-1 production.Poult. Sci. 70: 1372-1380.
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