|Application ||WB, IP, Func|
|Calculated MW||23686 Da|
|Purification||Antisera to chicken Interferon Beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography on protein G.|
|Immunogen||Recombinant chicken Interferon Beta.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interferon type B, IFN-beta, IFNB, IFN2|
|Target/Specificity||Rabbit anti-Chicken Interferon beta antibody recognizes chicken Interferon beta (chIFN-beta). Reports suggest that chIFN exhibits properties similar to mammalian IFN type I (IFNI).Functional studies revealed the presence of two distantly related IFNI genes, designated as IFN alpha and IFN beta, found on chicken chromosome Z. The serological distinction between these two IFNs has been verified using neutralisation assays, and there is evidence that the antiviral activity of chIFN-beta is approximately ten-fold less compared to chIFN-alpha. This would suggest that chIFNbeta might have a different physiological role, though chIFN-beta is expressed strongly in virus-infected cells. Rabbit anti-Chicken Interferon beta antibody (ABD11505) does not cross react with IFN gamma.This antiserum neutralizes chIFN-beta and can be used to discriminate IFN alpha and IFN beta bioactivities, (Schwarz, H.et al.).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Chicken Interferon beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Schwarz, H.et al. (2004) Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay.J. Interferon Cytokine Res. 24: 179-184.1. Staeheli, P. et al. (2001) Cytokines of Birds: Conserved functions – A largely different look.J. Interferon Cytokine Res. 21: 993-1010.2. Sick, C. et al. (1996) A family of genes coding for two serologically distinct chicken interferonsJ. Biol. Chem. 271: 7635-7639.
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