|Application ||WB, E, Func|
|Calculated MW||18953 Da|
|Purification||Antisera to chicken Interferon Gamma were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography on protein G.|
|Immunogen||Recombinant chicken Interferon Gamma|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interferon gamma, IFN-gamma, IFNG|
|Target/Specificity||ABD11506 recognizes chicken Interferon gamma (chIFN-gamma). Original studies investigating the properties of chicken Interferon (chIFN), revealed properties similar to mammalian IFN type I (IFNI), and it has since become apparent that there are at least three distinct chicken interferon proteins, designated as chIFN-alpha, chIFN-beta and chIFN-gamma. chIFN-gamma was first identified, when supernatant from chicken spleen cells stimulated with concanavalin A (ConA ), displayed macrophage-activating factor (MAF) activity - the principle function of mammalian type II IFN-gamma. Several independent studies have since supported the existence of this chicken homolog, by the cloning of IFN-gamma cDNA from activated chicken T cells and demonstrating that recombinant chicken IFN-gamma strongly upregulates the expression of MHC class II and iNOS genes. ABD11506, can be used to neutralize chIFN-gamma activity and to discriminate the antiviral activity of chIFN-gamma from that of chIFN-alpha and chIFN-beta, see Weining, K.C. et al. for details.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Chicken Interferon gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Staeheli, P. et al. (2001) Cytokines of Birds: Conserved functions – A largely different look.J. Interferon Cytokine Res. 21: 993-1010. 2. Weining, K.C. et al. (1996) Biological properties of recombinant chicken interferon-gamma.Eur. J. Immunol. 26: 2440-2447. 3. Schultz, U. et al. (1995) Recombinant chicken interferon: a potent antiviral agent that lacks intrinsic macrophage activating factor activity.Eur. J. Immunol. 25: 847-851.
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