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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti-Human Caspase-5 Antibody    

Anti-Human Caspase-5 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-Human Caspase-5 Antibody  ABD11512
    Immunocytochemical staining of P815 mouse mastocytoma cells with Rabbit anti Human caspase-5
  • WB - Anti-Human Caspase-5 Antibody  ABD11512
    Western blot analysis of whole cell lysate from Ramos, Burkitt's lymphoma deribed B-lymphoblastoid cells probed with Rabbit anti Human caspase-5 at 0.5(A), 1(B) and 2(C) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51878
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 49736 Da
Additional Information
Purification Purified IgG was prepared by affinity chromatography.
Immunogen A 14 amino acid peptide from the centre of human Caspase-5.
Shelf Life 18 months from date of despatch.
Gene ID 838
Other Names Caspase-5, CASP-5,, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3
Target/Specificity Rabbit anti-Human Caspase-5 antibody recognizes an epitope located within the internal region of human Caspase-5, a 47kDa cysteine protease, otherwise known as ICH-3. Caspase-5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes.Caspase-5 is a member of a growing number of inflammatory caspases belonging to the Caspase-1 (ICE-type) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase-1, Caspase-5 is not directly responsible for the activation of IL-1Beta from the pro-IL-1Beta precursor, but the presence of Caspase-5 does appear to enhance the processing of IL-1Beta.Thein vivo expression of Caspase-5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase-5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)-induced apoptosis (Wanget al.1996).
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Caspase-5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Wang, S. et al. (1996) Identification and characterization of Ich-3, a member of the Interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.
J. Biol. Chem. 271: 20580-20587.2. Lin, X.Y. et al. (2000) Expression analysis of the human Caspase-1 subfamily reveals specific regulation of the CASP5 gene by Lipopolysaccharide and Interferon-gamma.
J. Biol. Chem. 275: 39920-39926.3. Munday, N.A. et al. (1995) Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.
J. Biol. Chem. 270: 15870-15876.4. Cohen, G.M. (1997) Caspases: the executioners of apoptosis.
Biochem. J. 326: 1-16.

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$ 240.00
Cat# ABD11512
1 Formats Available
Availability: 5-7days
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